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There are risposta negativa data on pregnancy exposures Durante primates corresponding to periods prior to the third trimester Sopra humans.

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Because such patients may be less aware of certain of the milder adverse effects of barbiturates, the incidence of these reactions may be somewhat higher Per fully ambulatory patients.

Barbiturates may be habit forming. Tolerance, psychological and physical dependence may occur with continued use. (See “Drug Abuse And Dependence” and “Pharmacokinetics” sections.) Patients who have psychological dependence on barbiturates may increase the dosage or decrease the dosage interval without consulting a physician and may subsequently develop a physical dependence on barbiturates. To minimize the possibility of overdosage or the development of dependence, the prescribing and dispensing of sedative-hypnotic barbiturates should be limited to the amount required for the interval until the next appointment.

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Dosage adjustment of corticosteroid may be required; closely monitor patients (especially asthmatics) receiving corticosteroids when pentobarbital is initiated

Barbiturates were first synthesized Con the late 19th century and used extensively Con the early 20th century for a variety of conditions, including insomnia, anxiety, neonatal abstinence syndrome, and migraine. Con any case, utilization has declined lately because of the accessibility of more secure and more compelling meds.

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Barbiturates are absorbed Con varying degrees following oral, rectal, or parenteral administration. The salts are more rapidly absorbed than are the acids.

Barbiturates are substituted pyrimidine derivatives in which the basic structure common to these drugs is barbituric acid, a substance which has mai central nervous system (CNS) activity. CNS activity is obtained by substituting alkyl, alkenyl, or aryl groups on the pyrimidine ring.

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